Supplementary Information for

Files

• Supplemental Material: Supplemental Methods, References, and Figures
• Supplemental File S1: GTEx samples analyzed in this study
• Supplemental File S2: Primer and nucleotide sequences used in miRNA transfection experiments
• Supplemental File S3: GTEx heart (left ventricle) samples obtained for proteomic analysis
• Supplemental Code: Zip file of codes written for this study

Tables

• Supplemental Table S1: MSY genes and their X-linked homologs
• Supplemental Table S2: Gene mappability vs. expression level when multi-mapping reads are included or discarded
• Supplemental Table S3: Median expression level (TPM) of MSY genes among samples from each tissue
• Supplemental Table S4: Median expression level (TPM) of X homologs of MSY genes among XY samples from each tissue
• Supplemental Table S5: Median expression level (TPM) of X homologs of MSY genes among XX samples from each tisse
• Supplemental Table S6: Median Y/X expression ratios for X-Y gene pairs among samples from each tissue
• Supplemental Table S7: Co-expression of the X and Y homologs of each widely expressed X-Y gene pair in each tissue
• Supplemental Table S8: Results of tissue-vs-tissue differential expression analysis for X and Y homologs
• Supplemental Table S9: miRNA target sites in X-Y pair genes
• Supplemental Table S10: Accession numbers for EIF1AX/EIF1AY homolog sequences used in alignments
• Supplemental Table S11: Sex-biased expression of X-Y pairs, using the sum of X- and Y-homolog expression in XY samples
• Supplemental Table S12: Signal/noise values for individual peptides in individual heart tissue samples
• Supplemental Table S13: Relative protein abundances of X and Y isoforms in heart tissue samples
• Supplemental Table S14: Initial estimates of protein abundance in 33 human heart tissue samples, using reductionist approach to assign peptides to proteins (refer to Supplemental Table S13 for levels of X and Y isoforms)