Supplementary Table 1: MSY genes and gene families demonstrated or hypothesized to encode proteins (expanded version)

MSY
sequence
class
Gene
symbol
Gene name Alias # of
copies'
Tissue
expression
# of
exons
Length of
predicted
protein
(amino
acids)
Pseudo-
genes
on the Y
First published
reference
GenBank
accession
no.
X
homolog
First published
reference
GenBank
accession
no.
for X
homolog
Autosomal
homolog
X-transposed TGIF2LY TGFB-induced factor 2-like, Y-linked 1 Testis 2 185 no This study AF332223 TGIF2LX This study AF497480
PCDH11Y Protocadherin 11 Y 1 Fetal brain,
brain
3 [5] 1048
[1430]
no Yoshida K & Sugano S. Genomics 62, 540 (1999) AF332216
AF332217
PCDH11X Yoshida K & Sugano S. Genomics 62, 540 (1999) AB026187
AF332218
Total: 2
X-degenerate SRY Sex determining region Y 1 Testis 1 204 no Sinclair AH, et al. Nature 346, 240 (1990) X53772 SOX3 Stevanovic M, et al. Hum. Mol. Genet. 2, 2013 (1993) X71135
RPS4Y1 Ribosomal protein S4 Y isoform 1 1 Ubiquitous 7 263 no Fisher EMC, et al. Cell 63, 1205 (1990) M58459 RPS4X Fisher EMC, et al. Cell 63, 1205 (1990) M58458
ZFY Zinc finger Y 1 Ubiquitous 10 801 no Page DC, et al. Cell 51, 1091 (1987) M30607 ZFX Schneider-Gadicke A, et al. Nature 342, 708 (1989) X59739
AMELY Amelogenin Y 1 Teeth 6 192 no Lau EC, et al. Genomics 4, 162 (1989) M86933 AMELX Salido EC, et al. Am. J. Hum. Genet. 50, 303 (1992) M86932
TBL1Y Transducin (beta)like 1 protein Y 1 Fetal brain,
prostate
19 [18]
[18]
522 yes This study AF332220
AF332221
AF332222
TBL1X Bassi MT, et al. Am. J. Hum. Genet. 64, 1604 (1999) Y12781
PRKY Protein kinase Y 1 Ubiquitous 8 277 no Schiebel K, et al. Hum. Mol. Genet. 6, 1985 (1997) Y15801 PRKX Schiebel K, et al. Hum. Mol. Genet. 6, 1985(1997) X85545
USP9Y Ubiquitin specific protease 9 Y DFFRY 1 Ubiquitous 46 2555 yes Lahn BT & Page DC. Science 278, 675 (1997) AF000986 USP9X
(alias DFFRX)
Jones MH, et al. Hum. Mol. Genet. 5, 1695 (1996) X98296
DBY Dead box Y 1 Ubiquitous 17 660 no Lahn BT & Page DC. Science 278, 675 (1997) AF000985
AF000984
DBX Lahn BT & Page DC. Science 278, 675 (1997) AF000983
AF000982
UTY Ubiquitous TPR motif Y 1 Ubiquitous 20
[25]
1079
[1240]
[1347]
no Lahn BT & Page DC. Science 278, 675 (1997) AF000996
AF000995
AF000994
UTX Lahn BT & Page DC. Science 278, 675 (1997) AF000992
AF000993
TMSB4Y Thymosin (beta)4 Y TB4Y 1 Ubiquitous 2 80 no Lahn BT & Page DC. Science 278, 675 (1997) AF000989 TMSB4X
(alias TB4X)
Gondo H, et al. J. Immunolo. 139, 3840 (1987) M17733
NLGN4Y Neuroligin 4 isoform Y 1 Fetal brain,
brain, testis,
prostate
6 648 no Nagase T, et al. DNA Res. 6, 63 (1999) AB023168 NLGN4X Nagase T, et al. DNA Res. 6, 63 (1999) AB033086
CYorf15A Chromosome Y open reading frame 15A 1 Ubiquitous 4 182 no This study AF332224 CXorf15
(alias FLJ11209)
Isogai T, et al. GenBank AK002071 AK002071
CYorf15B Chromosome Y open reading frame 15B 1 Ubiquitous 4 181 no This study AF332225 CXorf15 Isogai T, et al. GenBank AK002071 AK002071
SMCY SMC (mouse) homolog, Y 1 Ubiquitous 27 1539 yes Agulnik AI, et al. Hum. Mol. Genet. 3, 873 (1994) U52191 SMCX Wu J, et al. Hum. Mol. Genet. 3, 153-60 (1994) L25270
EIF1AY Translation initiation factor 1A Y 1 Ubiquitous 7 144 no Lahn BT & Page DC. Science278, 675 (1997) AF000987 EIF1AX Dever TE, et al. J. Biol. Chem. 269, 3212 (1994) L18960
RPS4Y2 Ribosomal protein S4 Y isoform 2 1 Testis,
prostate
7 263 no This study AF497481 RPS4X Fisher EMC, et al. Cell 63, 1205 (1990) M58458
Total: 16
Ampliconic TSPY Testis specific protein Y ~35 Testis 6 308 yes Arnemann J, et al. Nucleic Acids Res. 15, 8713 (1987) M98525 TSPYL
VCY Variable charge Y BPY1 2 Testis 2 125 no Lahn BT & Page DC. Science 278, 675 (1997) AF000979 VCX Lahn BT & Page DC. Hum. Mol. Genet. 9, 311 (2000) AF159127
XKRY XK related Y 2 Testis 1 159 yes Lahn BT & Page DC. Science 278, 675 (1997) AF000997
CDY Chromodomain Y 4 Testis 1 541 yes Lahn BT & Page DC. Science 278, 675 (1997) AF080598 CDYL
HSFY Heat shock transcription factor Y 2 Testis 2 203
[401]
no This study AF332226
AF332227
RBMY RNA binding motif Y YRRM 6 Testis 12 496 yes Ma K, et al. Cell 75, 1287 (1993) X76059 RBMX Le Coniat M, et al. Hum. Genet. 88, 593 (1992) Z23064
PRY PTP-BL related Y 2 Testis 5 147 yes Lahn BT & Page DC. Science 278, 675 (1997) AF000988
BPY2 Basic protein Y 2 3 Testis 7 106 yes Lahn BT & Page DC. Science 278, 675 (1997) AF000980
DAZ Deleted in azoospermia 4 Testis 20-28 486-744 no Reijo R, et al. Nature Genet. 10, 383 (1995) AF248481
AF248482
AF248483
AF248480
DAZL
Total: ~60
Grand
total:
~78
' Excluding pseudogenes
* Genes first reported in this study.
[#] numbers in brackets correspond to splice variants