Supplementary Note 9

Two faster, less costly strategies have been employed recently in sequencing large genomes: whole-genome shotgun analysis^1,2, and sequencing a tiling path of mapped clones^3-8.

1. Venter, J. C. et al. The sequence of the human genome. Science 291, 1304-51. (2001).

2. Adams, M. et al. The genome sequence of Drosophila melanogaster. Science 287, 2185-2195 (2000).

3. Goffeau, A. et al. Life with 6000 genes. Science 274, 546, 563-567 (1996).

4. The C. elegans Sequencing Consortium. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282, 2012-2018 (1998).

5. Dunham, I. et al. The DNA sequence of human chromosome 22. Nature 402, 489-495 (1999).

6. Hattori, M. et al. The DNA sequence of human chromosome 21. Nature 405, 311-319 (2000).

7. Deloukas, P. et al. The DNA sequence and comparative analysis of human chromosome 20. Nature 414, 865-871 (2001).

8. International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 409, 860-921 (2001).