Supplementary Note 8, Supplementary References
The availability
of human MSY sequence has already enabled novel tests and rekindled debate of
Haldane’s hypothesis that mutations in the male germ line greatly outnumber
those in the female germ line1-3.
1. Haldane,
J. B. S. The mutation rate of the gene for haemophilia, and its segregation
ratios in males and females. Ann. Eugen.
13, 262-271 (1947).
2. Bohossian,
H. B., Skaletsky, H. & Page, D. C. Unexpectedly similar rates of nucleotide
substitution found in male and female hominids. Nature 406, 622-625
(2000).
3. Makova,
K. D. & Li, W. H. Strong male-driven evolution of DNA sequences in humans
and apes. Nature 416, 624-626 (2002).