Supplementary Note 2

To date, efforts to gain sequence-based understanding of entire human chromosomes have largely bypassed heterochromatic regions^1-6.

1. Dunham, I. et al. The DNA sequence of human chromosome 22. Nature 402, 489-495 (1999).

2. Hattori, M. et al. The DNA sequence of human chromosome 21. Nature 405, 311-319 (2000).

3. Deloukas, P. et al. The DNA sequence and comparative analysis of human chromosome 20. Nature 414, 865-871 (2001).

4. International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 409, 860-921 (2001).

5. Venter, J. C. et al. The sequence of the human genome. Science 291, 1304-51. (2001).

6. Heilig, R. et al. The DNA sequence and analysis of human chromosome 14. Nature 421, 601-607 (2003).