Supplementary Materials for
Sahin Naqvi, Alexander K. Godfrey, Jennifer F. Hughes, Mary L. Goodheart, Richard N. Mitchell, David C. Page
Conservation, acquisition, and functional impact of sex-biased gene expression in mammals
Science 365, eaaw7317 (2019)
Materials/Methods, Supplementary Text, Tables, Figures, and/or References
- Materials and Methods
- Figs. S1 to S26
- Tables S3 to S8
- Captions for Tables S1, S2, S4 to S7, and S9
Metadata for non-human RNA-seq libraries.
Metadata for analyzed human GTEx RNA-seq libraries.
Information on tissue-specific sex-biased expression, orthology assignment, and additional gene-level attributes as well as empirically estimated false discovery rates for each evolutionary class of sex bias in each tissue.
Height TWAS Z-scores and sex bias assignments for all gene-tissue pairs.
Within-tissue Gene Ontology enrichments for genes with either conserved or acquired sex bias relative to those without. Output from PANTHER statistical overrepresentation test with genes with conserved or acquired male or female bias as foreground and all genes expressed in the tissue as background. Enrichments for genes with conserved sex bias and calculated TWAS Z-score in the same tissue are also provided.
Sex bias estimates in the cattle pituitary gland, from Seo et al, (2016).
Information on motifs for sex-biased transcription factors correlated with gains or losses of sex bias.