Supplementary Materials for
Sahin Naqvi, Alexander K. Godfrey, Jennifer F. Hughes, Mary L. Goodheart, Richard N. Mitchell, David C. Page
Conservation, acquisition, and functional impact of sex-biased gene expression in mammals
Science 365, eaaw7317 (2019)
Materials/Methods, Supplementary Text, Tables, Figures, and/or References
Supplementary Methods:
- Materials and Methods
- Figs. S1 to S26
- Tables S3 to S8
- Captions for Tables S1, S2, S4 to S7, and S9
- References
Table S1
Metadata for non-human RNA-seq libraries.
Table S2
Metadata for analyzed human GTEx RNA-seq libraries.
Table S4
Information on tissue-specific sex-biased expression, orthology assignment, and additional gene-level attributes as well as empirically estimated false discovery rates for each evolutionary class of sex bias in each tissue.
Table S5
Height TWAS Z-scores and sex bias assignments for all gene-tissue pairs.
Table S6
Within-tissue Gene Ontology enrichments for genes with either conserved or acquired sex bias relative to those without. Output from PANTHER statistical overrepresentation test with genes with conserved or acquired male or female bias as foreground and all genes expressed in the tissue as background. Enrichments for genes with conserved sex bias and calculated TWAS Z-score in the same tissue are also provided.
Table S7
Sex bias estimates in the cattle pituitary gland, from Seo et al, (2016).
Table S9
Information on motifs for sex-biased transcription factors correlated with gains or losses of sex bias.