Supplementary Information for
Lange, J., Skaletsky, H., van Daalen, S.K.M., Embry, S.L., Korver, C.M., Brown, L.G., Oates, R.D., Silber, S., Repping, S., Page, D.C.
Isodicentric Y Chromosomes and Sex Disorders as Byproducts of Homologous Recombination That Maintains Palindromes.
Cell 138: 855-869 (4 September 2009)
Files
- Supplementary Information Includes:
- Supplemental Experimental Procedures
- Supplemental Figures
- Figure S1. Triangular dot plot of the MSY reference sequence shows intrachromosomal sequence similarities
- Figure S2. STS content of structurally anomalous Y chromosomes in 85 individuals with deletion breakpoints in the long arm (Yq) or centromere
- Figure S3. Comprehensive results of testing for duplication, in idicYp chromosomes, of sequences immediately proximal to targeted palindromes
- Figure S4. Comprehensive results of testing the copy number, in idicYp chromosomes with breakpoints in palindrome P1, of sequences located between P1 and P5
- Figure S5. Comprehensive results of testing for duplication, in isoYp or idicYp chromosomes, of sequences immediately proximal to targeted heterochromatic repeat
- Figure S6. STS content of structurally anomalous Y chromosomes in two individuals with deletion breakpoints in the short arm (Yp)
- Figure S7. Comprehensive results of testing for duplication, in an idicYq, of sequences immediately proximal to Yp inverted repeat IR3
- Figure S8. Results of testing centromere function in structurally dicentric (idicYp) chromosomes
- Figure S9. Molecular signatures of 23 idicY and isoY chromosomes predicted to form by ectopic homologous recombination events involving MSY palindromes, inverted repeats, and highly repetitive heterochromatic regions
- Supplemental Tables
- Table S1. Deletion breakpoint intervals of 85 individuals with breakpoints in the long arm (Yq) or centromere, and of two individuals with breakpoints in the short arm (Yp) of the MSY
- Table S2. Characteristics of observed and predicted idicY and isoY chromosomes
- Table S3. Y chromosome gene content and copy number of 23 idicY and isoY chromosomes predicted to form by ectopic homologous recombination events involving MSY palindromes, inverted repeats, and highly repetitive heterochromatic regions
- Table S4. STSs used in the analysis of Y chromosome content
- Table S5. Metaphase and interphase FISH assays of Y chromosome structure in individuals with breakpoints in the MSY
- Supplemental References