Supplementary Information

Supplementary Information for

Dokshin GA, Baltus AE, Eppig JJ, Page DC.

Oocyte differentiation is genetically dissociable from meiosis in mice. Nature Genetics 45, 877 (2013)

Figure S1 Stra8 is required for meiotic initiation in ovarian germ cellson C57BL/6 inbred background employed throughout this study.
Figure S2 Stra8-deficient ovaries are depleted of germ cells by sixweeks of age.
Figure S3 Stra8-deficient ovarian germ cells survive postnatally.
Figure S4 In Stra8-deficient ovaries, germ cells grow and differentiate during first postnatal week.
Figure S5 Stra8-deficientoocyte-like cells form polar bodies upon ovulation.
Figure S6 Some Stra8-deficient oocyte-like cells exhibit spindle assembly defects resulting from absence of meiotic prophase.
Figure S7 Stra8-deficient oocyte-like cells contain significantly less DNA than wild-type oocytes at GV stage.