Information for

Figures

• Extended Data Figure 1.      Annotated sequence contigs from MSY of five species. (The legend)
• Extended Data Figure 2.      Expression of Y-linked genes across tissues and species. (The legend)
• Extended Data Figure 3.      Dot plot of human X orthologs in opossum and chicken. (The legend)
• Extended Data Figure 4.      Phylogenetic analysis of stratum one and stratum two (The legend)
• Extended Data Figure 5.      Phylogenetic tree showing X-Y gene conversion in AMELX/AMELY and ZFX/ZFY. (The legend)
• Extended Data Figure 6.      Y-Y gene conversion within multi-copy gene families. (The legend)
• Extended Data Figure 7.      Viable structually variant sex chromosomes in humans. (The legend)

Tables

• Extended Data Table 1.      PANTHER statistical overrepresentation results.
• Extended Data Table 2.      Accession numbers of mouse pseudoautosomal region genes.
• Extended Data Table 3.      Patients with structurally varuant X and Y Chromosomes.
• Source Data Figure 1.        Status of ancestral genes in each lineage
• Source Data Figure 4.        Constraints on dynamics of Y-chromosome gene content
• Source Data Figure 5.        Includes:
  • 5a    Branch lengths for multi-copy and single-copy X-Y pair genes
  • 5b    Human haploinsufficiency scores for ancestral genes
  • 5c    Calculated expression breadth for ancestral genes
  • 5d    Ensembl human-mouse dN/dS for ancestral genes
• Supplementary Tables. (XLS)      Includes:
  • 1: BAC clone accession numbers, and nucleotide positions in MSY sequence assemblies
  • 2: Ancestral genes
  • 3: Accession numbers of genes in this study
  • 4: PANTHER statistical overrepresentation results
  • 5: Values of dN, dS, and dN/dS for all X-Y pairs

Note

• Supplementary Notes. (PDF)      Include:
  • 1: SHIMS strategy and error estimates
  • 2: PANTHER Statistical Overrepresentation Test
  • 3: Identification and recalibration of evolutionary strata
  • 4: Modeling kinetics of Y-chromosome decay
  • 5: Haplolethality of broadly expressed, dosage-sensitive X-Y pair genes

Sequence Files

• Gene Alignments
• Gene Sequences